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In 40 healthy persons, 11 nondialyzed uremic patients and 27 dialyzed uremic patients, of whom 4 also had cancer, the selenium concentration in serum was determined. The mean serum selenium concentration in healthy persons was 13.6 +/- 0.8 micrograms/dl, in nondialyzed patients 11.9 +/- 1.9 micrograms/dl and in dialyzed uremic patients 11.3 +/- 1.0 micrograms/dl. There was a significant statistical difference between healthy persons and uremic patients (p less than 0.001), but not between dialyzed and nondialyzed uremic patients. The subgroup of cancer patients on hemodialysis also had low serum selenium concentrations. The possible role of low selenium levels as one of the factors responsible for the increased incidence of malignancy in patients with chronic renal failure is supported by several facts such as: low serum selenium levels detected in patients with malignant diseases; the higher cancer incidence in inhabitants of low-selenium areas, and the known ability of selenium to inhibit many types of experimental carcinogenesis.
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
January 1990,
International urology and nephrology,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
October 1995,
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS),
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
October 1988,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
July 1999,
Clinical and experimental immunology,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
November 1983,
The International journal of artificial organs,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
December 1983,
Kidney international. Supplement,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
April 2006,
Saudi medical journal,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
February 1987,
Scandinavian journal of clinical and laboratory investigation,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
November 1974,
Clinica chimica acta; international journal of clinical chemistry,
G Kallistratos, and
A Evangelou, and
K Seferiadis, and
P Vezyraki, and
K Barboutis
January 1996,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
