Biomaterial Database

Ventilation and oxygen consumption in the guinea pig. 1985

C I Blake, and N Banchero

Respiratory values were determined in guinea pigs studied under normal laboratory conditions in Denver. The effects of anesthesia and acute hypercapnia were also assessed. In normal laboratory conditions, VO2 and VE were proportional to body weight (BW). Specific VO2 and VE for small guinea pigs (mean BW: 269 g) were 1.14 +/- 0.04 (SEM) and 57.5 +/- 3.9 ml/g X h, respectively, compared to 0.82 +/- 0.03 (P less than 0.001) and 29.9 +/- 0.8 ml/g X h (P less than 0.001), respectively, for large animals (mean BW: 817 g). Tidal volume (VT) was related to BW by the following equation: VT (ml) = 3.97 X 10(-3) BW (g) + 2.05 (r = 0.82; P less than 0.001). During anesthesia VO2 decreased 25-63% and VE was reduced by 45% in those animals having the largest change in VO2. In hypercapnia, VE was more than twice that in normocapnia primarily due to a 75-95% elevation in VT.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010424	Pentobarbital	A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)	Mebubarbital,Mebumal,Diabutal,Etaminal,Ethaminal,Nembutal,Pentobarbital Sodium,Pentobarbital, Monosodium Salt,Pentobarbitone,Sagatal,Monosodium Salt Pentobarbital
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006935	Hypercapnia	A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
D000758	Anesthesia	A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013990	Tidal Volume	The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.	Tidal Volumes,Volume, Tidal,Volumes, Tidal