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Potential cytotoxic compounds (spindle poisons) are being designed for the treatment of prostatic carcinoma, using the structural requirements of the substrates for prostatic acid phosphatase (PAP). Colchicine has been modified in ring C to give colchiceinamides of substituted ethanolamines and ethanolaminephosphates. Another new series of compounds modifying ring B of thiocolchicine have been prepared. Three O-phosphates of the thiocolchicine series have also been made. One has been examined for its specificity toward PAP. Some toxicity data of these compounds in mice have also been reported. Colchiceinamide-(L)-ephedrinephosphate has been examined in stumptail monkeys and some preliminary results are reported here.
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
January 1975,
Cancer chemotherapy reports,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
November 1979,
The Medical letter on drugs and therapeutics,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
January 1979,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
March 1981,
Urology,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
May 1943,
British medical journal,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
September 1969,
Schweizerische medizinische Wochenschrift,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
June 1981,
JAMA,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
November 1984,
Hinyokika kiyo. Acta urologica Japonica,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
December 1982,
Clinical chemistry,
B D Paul, and
J A Serrano, and
A E Friedman, and
I J Sarlos, and
N J Sternberger, and
H L Wasserkrug, and
A M Seligman
July 1959,
American journal of clinical pathology,
