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Radioimmunoassays for both human copper-zinc and manganous superoxide dismutases (Cu-Zn SOD and Mn SOD, respectively) have been developed, validated, and utilized to measure the concentrations of these enzymes in cultured monocytes. Monocyte Mn SOD increased 4.7-fold over basal during 3 days of culture, an increase that was markedly enhanced by stimulation with bacterial lipopolysaccharide (LPS). Cu-Zn SOD showed a transient decrease over the culture period but was unaffected by LPS. Stimulation with muramyl dipeptide had minimal effect on Mn SOD and no effect on Cu-Zn SOD during culture, even at a concentration capable of activating the monocytes, as defined by zymosan-induced superoxide production.
K Asayama, and
R L Janco, and
I M Burr
December 1997,
Archives of biochemistry and biophysics,
K Asayama, and
R L Janco, and
I M Burr
November 1988,
Science (New York, N.Y.),
K Asayama, and
R L Janco, and
I M Burr
April 2008,
Journal of the American Chemical Society,
K Asayama, and
R L Janco, and
I M Burr
June 2003,
The Journal of biological chemistry,
K Asayama, and
R L Janco, and
I M Burr
August 2013,
Free radical biology & medicine,
K Asayama, and
R L Janco, and
I M Burr
February 1992,
International journal of cancer,
K Asayama, and
R L Janco, and
I M Burr
January 1994,
American journal of respiratory cell and molecular biology,
K Asayama, and
R L Janco, and
I M Burr
February 1995,
Gene,
K Asayama, and
R L Janco, and
I M Burr
July 1999,
International journal of cancer,
K Asayama, and
R L Janco, and
I M Burr
November 1994,
Journal of cellular physiology,
