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In vitro binding of tetracycline, gentamicin, erythromycin and rifampicin by the liver organoids and intracellular distribution of the antibiotics in the hepatocytes of rats with acute irradiation disease were studied. Total gamma-irradiation of the animals with 60Co in a dose of 750 R resulted in the development of a typical radiation disease and induced pronounced changes in binding of tetracycline, gentamicin and erythromycin by isolated subcellular fractions. Simultaneous impairment of the antibiotic intracellular distribution was observed. Rifampicin interaction with the cell structures was unchanged. It is suggested that there is a relation between the level of the impairment of the antibiotic cell pharmacokinetics in acute radiation disease and the mechanism of the drug intracellular binding in health.
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
July 1954,
Canadian journal of biochemistry and physiology,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
January 1988,
The International journal of biochemistry,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
June 1957,
The Journal of biological chemistry,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
May 1970,
The Biochemical journal,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
January 1989,
The International journal of biochemistry,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
January 1967,
Indian journal of experimental biology,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
January 1970,
Izvestiia na Instituta po fiziologiia,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
March 1982,
Analytical biochemistry,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
May 1980,
Acta pharmacologica et toxicologica,
G Ia Kivman, and
A E Guliaev, and
V A Kulishov, and
B A Nadirova, and
K G Cherevko
December 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
