Biomaterial Database

Neutrophil and monocyte chemotaxis in pustulosis palmo-plantaris and pustular psoriasis. 1985

T Ternowitz, and K Thestrup-Pedersen

Polymorphonuclear leukocyte (PMN) and monocyte (MN) chemotaxis in nine patients with pustulosis palmo-plantaris (PPP) and ten patients with pustular psoriasis (PP) was determined by an objective in vitro assay employing a 51Cr-labelling technique. PMN chemotaxis was significantly enhanced in both groups of patients compared with controls. MN chemotaxis was normal. There was no difference in the chemotactic responsiveness of leukocytes from patients with PPP and PP. The random migration of PMN and MN from the patients was normal. Homogenized tissue specimens from lesional skin with and without pustules, and from perilesional, normal-looking skin of PPP and PP were analysed for the presence of chemoattractant(s) for PMN. Lesional skin had considerable chemoattractant properties, but perilesional skin did not induce directed migration of PMNs.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009000	Monocytes	Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.	Monocyte
D009504	Neutrophils	Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.	LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D011565	Psoriasis	A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D002630	Chemotactic Factors	Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.	Chemoattractant,Chemotactic Factor,Chemotaxin,Chemotaxins,Cytotaxinogens,Cytotaxins,Macrophage Chemotactic Factor,Chemoattractants,Chemotactic Factors, Macrophage,Macrophage Chemotactic Factors,Chemotactic Factor, Macrophage,Factor, Chemotactic,Factor, Macrophage Chemotactic
D002634	Chemotaxis, Leukocyte	The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.	Leukotaxis,Leukocyte Chemotaxis
D005260	Female		Females
D005533	Foot Dermatoses	Skin diseases of the foot, general or unspecified.	Foot Dermatosis,Dermatoses, Foot,Dermatosis, Foot
D006229	Hand Dermatoses	Skin diseases involving the HANDS.	Hand Dermatosis,Dermatoses, Hand,Dermatosis, Hand