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We have studied 30 women with symptomatic benign breast disease in order to test the hypothesis that in some it might be caused by an enzyme variant leading to excessive adrenal production of oestrone. Synthetic 1-24 ACTH (Synacthen) was given intramuscularly after overnight suppression with dexamethasone, during the early follicular phase of the menstrual cycle. In no subjects did plasma oestrone levels show a consistent and significant response to ACTH despite the expected consistent rises in androstenedione and cortisol. We conclude that it is unlikely that adrenal oestrogens play a significant role in the pathophysiology of even a minority of patients with benign breast disease.
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
January 1997,
Microbiology and immunology,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
February 1988,
The Journal of endocrinology,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
July 1999,
Journal of neuroendocrinology,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
May 1974,
Experimental cell research,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
December 2019,
Adipocyte,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
March 1989,
Clinical and experimental pharmacology & physiology,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
May 1982,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
December 1995,
Pharmacology, biochemistry, and behavior,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
March 2017,
Invertebrate neuroscience : IN,
C J Chandler, and
D M Large, and
D C Anderson, and
R A Sellwood
April 2016,
Microbiology (Reading, England),
