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The possible involvement of renal glutamine synthesis in the regulation of ammoniagenesis during metabolic acidosis has been investigated. Using an isotope dilution technique glutamine synthesis has been demonstrated in the intact perfused rat kidney, despite zero net balance for glutamine in this preparation. Inhibition of glutamine synthesis resulted in increased ammonia production in isolated cortical tubules. The rates of these processes were comparable. We conclude that recycling of nitrogen through glutamine synthesis and glutamine hydrolysis could play a quantitatively significant role in the control of ammonia excretion by the kidney, particularly in acute acidosis where the fall in pH seems to inhibit glutamine synthesis.
H Lanctin, and
J T Brosnan, and
B D Ross
April 1986,
The American journal of physiology,
H Lanctin, and
J T Brosnan, and
B D Ross
August 2002,
Archives of biochemistry and biophysics,
H Lanctin, and
J T Brosnan, and
B D Ross
October 1991,
Biochimica et biophysica acta,
H Lanctin, and
J T Brosnan, and
B D Ross
April 1990,
Prostaglandins, leukotrienes, and essential fatty acids,
H Lanctin, and
J T Brosnan, and
B D Ross
July 1988,
Pflugers Archiv : European journal of physiology,
H Lanctin, and
J T Brosnan, and
B D Ross
September 1985,
The Biochemical journal,
H Lanctin, and
J T Brosnan, and
B D Ross
March 1974,
The American journal of physiology,
H Lanctin, and
J T Brosnan, and
B D Ross
June 1986,
The American journal of physiology,
H Lanctin, and
J T Brosnan, and
B D Ross
July 1983,
Kidney international,
H Lanctin, and
J T Brosnan, and
B D Ross
October 1970,
The Journal of biological chemistry,
