-transparent.png){kind=logo}
The ocular pharmacokinetics of bendazac were studied in rabbits, following intravenous administration of bendazac lysine. The compound and its 5-hydroxyderivative were determined in different eye compartments and plasma by radioassay, using [14C]bendazac, and HPLC. The highest concentrations were found in the iris and in descending order in the ciliary body, retina, cornea, tears, aqueous humor, vitreous, and lens. The time course of concentrations in the plasma, aqueous and vitreous humor, ciliary body, and retina showed kinetics described by the exponential equation y = aebx with a half-life of 2.47, 4.56, 3.59, and 3.22 hr, respectively; in the lens the half-life was 17.77 hr.
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
December 1984,
Il Farmaco; edizione pratica,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
October 1992,
Arzneimittel-Forschung,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
March 1998,
Naunyn-Schmiedeberg's archives of pharmacology,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
January 1994,
Life sciences,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
November 1999,
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
January 1994,
Journal of ocular pharmacology,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
January 2006,
European journal of ophthalmology,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
August 2011,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
March 1984,
Archives of ophthalmology (Chicago, Ill. : 1960),
P Valeri, and
M Palmery, and
B Tita, and
B Silvestrini
March 1997,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
