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A native of the Peruvian Andes (4,250 m) was studied before and after isovolemic hemodilution of the hematocrit from 62 to 42%. O2 transport was studied with newly developed catheters in the radial and pulmonary arteries. These catheters allowed continuous measurement of arteriovenous O2 content and intermittent cardiac output by thermodilution. During exercise tests, breath-by-breath gas exchange measurements also allowed cardiac output to be calculated by the O2-Fick technique. A complex series of interrelated physiological changes occurred in response to hemodilution. These included increased ventilation, increased arterial and mixed venous PO2, increased cardiac output (both heart rate and stroke volume), and improved ventilation-flow match. The general improvement in symptoms that followed hemodilution correlated well with increased anaerobic threshold and mixed venous PO2 during exercise.
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
September 1976,
Respiration physiology,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
January 2005,
Haematologica,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
March 1985,
Journal of applied physiology (Bethesda, Md. : 1985),
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
March 1997,
Acta physiologica Scandinavica,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
August 1951,
The American journal of physiology,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
July 1992,
The Journal of pediatrics,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
July 2020,
Proteomics,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
December 1978,
Journal of applied physiology: respiratory, environmental and exercise physiology,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
January 1985,
Advances in experimental medicine and biology,
R M Winslow, and
C C Monge, and
E G Brown, and
H G Klein, and
F Sarnquist, and
N J Winslow, and
S S McKneally
November 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
