Biomaterial Database

The biocompatibility of a dental Ag-Pd-Cu-Au-based casting alloy and its structural components. 1985

L Niemi, and S Syrjänen, and A Hensten-Pettersen

The biocompatibility of type III casting gold alloy, an Ag-Pd-Cu-Au-based dental casting alloy and its two main structural components, a CuPd-rich and an Ag-rich phase, was studied after subcutaneous implantation for 7 weeks in 20 guinea pigs. The Ag-Pd-Cu-Au alloy was surrounded by a capsule of immature collagen with fibroblasts and an increased vascular supply. The CuPd-rich component induced and maintained an acute inflammation with highly vascularized granulation tissue. The tissue reaction to the Ag-rich component and the Au-based alloy was slight. Ten of the guinea pigs were sensitized to PdCl2 prior to the implantation period, but this caused no enhanced tissue reaction, except for an increase in the number of mast cells around three of the alloys.

UI	MeSH Term	Description	Entries
D007249	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008407	Mast Cells	Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.	Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D010165	Palladium	A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
D003238	Connective Tissue	Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.	Connective Tissues,Tissue, Connective,Tissues, Connective
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D003722	Dental Alloys	A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions for use in restorative or prosthetic dentistry.	Alloy, Dental,Alloys, Dental,Dental Alloy
D003734	Dental Casting Investment	Material from which the casting mold is made in the fabrication of gold or cobalt-chromium castings. (Boucher's Clinical Dental Terminology, 4th ed, p168)	Casting Investment, Dental,Casting Investments, Dental,Dental Casting Investments,Investment, Dental Casting,Investments, Dental Casting
D005260	Female		Females
D006046	Gold	A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea