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Serum immunoglobulin (Ig) A and IgG gliadin antibodies were determined with a simple, rapid, and inexpensive method--diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA)--and the results were related to small intestinal mucosal morphology in 234 children suspected of having malabsorption. Fifty-six of 58 children with flat intestinal mucosa had increased IgA and/or IgG gliadin antibody levels (sensitivity 97%). Fifty-four of the 58 children had celiac disease (CD) (n = 25) or probable CD (n = 29). Four children with flat mucosa had cow's milk protein and/or soy protein intolerance and three of these had increased gliadin antibody levels. Seventeen percent of 132 children with normal intestinal mucosa had increased IgA and/or IgG gliadin antibody levels. IgA and IgG gliadin antibody levels decreased significantly in the celiac children on a gluten-free diet and increased significantly after gluten challenge. Determination of serum IgA and IgG gliadin antibodies by means of DIG-ELISA is a sensitive test for small intestinal mucosal damage in children. When malabsorption is suspected, we suggest that this assay be used to select children for a small intestinal biopsy. It is also very useful for the follow-up of adherence to a gluten-free diet and to determine the effect of gluten challenge in celiac children.
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
December 1981,
The British journal of dermatology,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
August 1991,
Journal of pediatric gastroenterology and nutrition,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
January 1987,
La Ricerca in clinica e in laboratorio,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
November 2007,
Current HIV research,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
July 2016,
The British journal of dermatology,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
May 1990,
Clinical and experimental immunology,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
July 1986,
Lancet (London, England),
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
May 1994,
Scandinavian journal of gastroenterology,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
June 1986,
Clinical and experimental immunology,
T Lindberg, and
L A Nilsson, and
S Borulf, and
B Cavell, and
S P Fällström, and
U Jansson, and
L Stenhammar, and
G Stintzing
October 1992,
Journal of pediatric gastroenterology and nutrition,
