Biomaterial Database

Hemorrhage in DOC-salt hypertensive rats: plasma and platelet vasopressin. 1985

J T Crofton, and L Share, and D P Brooks

The effect of two consecutive hemorrhages, each 10% of blood volume, on plasma vasopressin concentrations was determined in conscious unilaterally nephrectomized Long-Evans rats made hypertensive by treatment for 3 wk with deoxycorticosterone (DOC) and substitution of 1% saline for drinking water (DOC-salt rats) or DOC alone (DOC rats) and in normotensive unilaterally nephrectomized rats drinking water (H2O rats) or saline (NaCl rats). In response to 20% hemorrhage, blood pressure decreased more (P less than 0.01) and plasma vasopressin increased less (P less than 0.01) in the DOC-salt rats than in the other groups. Under basal conditions, immunoreactive vasopressin was found in the platelets in NaCl, DOC, and DOC-salt rats (P less than 0.01) but not in H2O rats. Platelet vasopressin increased (P less than 0.05-0.01) in response to hemorrhage only in DOC-salt rats. In conclusion, the vasopressin response to hemorrhage in DOC-salt rats is impaired; platelet immunoreactive vasopressin is of little importance in normal rats but is increased by treatment with DOC and/or chronic salt loading; and platelet vasopressin increased in response to hemorrhage only in DOC-salt rats.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297	Male		Males
D009392	Nephrectomy	Excision of kidney.	Heminephrectomy,Heminephrectomies,Nephrectomies
D001792	Blood Platelets	Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.	Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D001810	Blood Volume	Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.	Blood Volumes,Volume, Blood,Volumes, Blood
D003900	Desoxycorticosterone	A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE	21-Hydroxyprogesterone,Cortexone,Deoxycorticosterone,Desoxycortone,11-Decorticosterone,21-Hydroxy-4-pregnene-3,20-dione,11 Decorticosterone,21 Hydroxy 4 pregnene 3,20 dione,21 Hydroxyprogesterone
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012462	Saline Solution, Hypertonic	Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).	Hypertonic Saline Solution,Hypertonic Solution, Saline,Sodium Chloride Solution, Hypertonic,Hypertonic Saline Solutions,Hypertonic Solutions, Saline,Saline Solutions, Hypertonic,Sodium Chloride Solutions, Hypertonic,Saline Hypertonic Solution,Saline Hypertonic Solutions,Solution, Hypertonic Saline,Solution, Saline Hypertonic,Solutions, Hypertonic Saline,Solutions, Saline Hypertonic
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor