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Calcium-tolerant ventricular myocytes from adult rats were electrically stimulated. The maximal contraction frequency (fm) was determined at different temperatures. In drug-free Tyrode solution, fm follows the Arrhenius equation from 7 to 39.5 degrees C. However, all investigated calcium antagonist drugs (verapamil, nifedipine, diltiazem, fendiline) introduce a discontinuity between 27 and 30 degrees C into the Arrhenius plots of fm. Above this transition temperature calcium antagonists lower fm more pronouncedly than below. Below, 10- or 100 fold higher concentrations are needed for the same relative effect as at 37 degrees C. It is argued that these findings might be important in cardiac surgery when calcium antagonists are used for cardioplegia at deep hypothermia.
H M Piper, and
J F Hütter, and
P G Spieckermann
January 1985,
Basic research in cardiology,
H M Piper, and
J F Hütter, and
P G Spieckermann
February 2008,
Neuroscience,
H M Piper, and
J F Hütter, and
P G Spieckermann
April 1966,
The Journal of pharmacology and experimental therapeutics,
H M Piper, and
J F Hütter, and
P G Spieckermann
November 2006,
Neuroscience,
H M Piper, and
J F Hütter, and
P G Spieckermann
February 1983,
Proceedings of the National Academy of Sciences of the United States of America,
H M Piper, and
J F Hütter, and
P G Spieckermann
January 1987,
Ginecologia y obstetricia de Mexico,
H M Piper, and
J F Hütter, and
P G Spieckermann
January 1982,
Microbiology and immunology,
H M Piper, and
J F Hütter, and
P G Spieckermann
August 1987,
Biochemical pharmacology,
H M Piper, and
J F Hütter, and
P G Spieckermann
October 1977,
Journal of neurology,
H M Piper, and
J F Hütter, and
P G Spieckermann
December 1985,
The Physiologist,
