The pharmacokinetics of bencyclane were studied in 4 healthy volunteers. In a randomized cross-over design, 35 and 70 mg of bencyclane were infused intravenously and 71 and 143 mg were given orally as a solution in water. After intravenous application bencyclane is distributed very rapidly into tissues (t1/2 approx. 7 min). The volume of distribution is about 600 l. In almost every subject the plasma levels rose again after this distribution phase. Bencyclane is eliminated mainly by metabolism. At the most 3% of the dose is excreted as unchanged drug in the urine. Total clearance is appr. 44 l/h, the elimination half-life approx. 12 h. Oral bioavailability ranges between 18 and 84%.