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The molecular nature of lethal and semilethal mutations in the Pgd locus of D. melanogaster coding for 6-phosphogluconate dehydrogenase (6PGD) was studied. All the 11 mutations affect the structural gene of the Pgd locus: 3 semilethal mutations resulted in altered 6PGD molecules with decreased catalytic activities; the rest 8 lethals were "null" alleles characterized by mutant polypeptides capable of reacting with antisera against highly purified 6PGD. "Null" or low activity alleles for glucose-6-phosphate dehydrogenase induced by ethyl methanesulfonate were shown to be suppressores for the lethal mutations in the Pgd locus. A monocistronic type of organization of the Pgd locus is suggested taking into account the biochemical mechanism of suppression of the Pgd-lethals and their location in the structural gene coding for 6PGD.
V A Gvozdev, and
T I Gerasimova, and
G L Kogan, and
J M Rosovsky
June 1977,
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V A Gvozdev, and
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V A Gvozdev, and
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V A Gvozdev, and
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V A Gvozdev, and
T I Gerasimova, and
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V A Gvozdev, and
T I Gerasimova, and
G L Kogan, and
J M Rosovsky
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