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Oncogenes of fibrosarcomas of rats, induced by subcutaneous injection of 1,8-dinitropyrene (1,8-DNP), were examined by NIH 3T3 cell transfection assay and Southern blot analysis. Transformants containing rat specific repetitive sequences were obtained with DNAs of 4 fibrosarcomas, 1,8-DNP1, 1,8-DNP2, 1,8-DNP3 and 1,8-DNP7. A transformant, 1,8-DNP2-2, induced by DNA of a fibrosarcoma, 1,8-DNP2, and 7 secondary transformants derived from it contained rat K-ras sequences. Another transformant, 1,8-DNP2-1, induced by the same sarcoma did not have a ras family oncogene. This indicates that the sarcoma, 1,8-DNP2, has at least 2 transforming genes. The transforming genes of 6 other transformants derived from 3 sarcomas did not contain ras family or neu transforming genes.
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
August 1988,
Carcinogenesis,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
February 1987,
Molecular and cellular biology,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
February 1991,
International journal of cancer,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
January 1997,
Oncology reports,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
May 1984,
Chemico-biological interactions,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
October 1988,
Carcinogenesis,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
October 1996,
Cancer letters,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
May 1993,
Blood,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
January 1990,
Mutagenesis,
M Ochiai, and
M Nagao, and
T Tahira, and
F Ishikawa, and
K Hayashi, and
H Ohgaki, and
M Terada, and
N Tsuchida, and
T Sugimura
January 1986,
Gene amplification and analysis,
