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This study examines the toxicity (as measured by reduced intracellular K+) and metabolism (defluorination) of halothane and enflurane in rat hepatocytes in suspension (RHS) with regards to O2 tension, time, and concentration. In 95% O2 halothane is more toxic than enflurane when RHS are exposed to 5-20 microliters of these anesthetics. At these levels halothane is not metabolized while enflurane is metabolized. At 21% O2 a similar pattern was seen with regards to toxicity. However, metabolism of halothane rapidly reached an elevated level while that of enflurane is reduced when compared to 95% O2. Thus toxicity of halothane and enflurane at these dose levels appears to be unrelated to metabolism and due solely to a solvent effect.
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
January 1978,
Anesthesiology,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
January 1975,
Acta anaesthesiologica Belgica,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
May 1976,
Journal of toxicology and environmental health,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
December 1994,
Human & experimental toxicology,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
April 1975,
Minerva anestesiologica,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
January 1987,
Presse medicale (Paris, France : 1983),
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
January 1975,
Acta anaesthesiologica Belgica,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
January 1975,
Acta anaesthesiologica Belgica,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
January 1992,
Journal de toxicologie clinique et experimentale,
A B DiRenzo, and
A J Gandolfi, and
S D Brooks, and
K Brendel
April 1972,
The Journal of the American Association of Nurse Anesthetists,
