Biomaterial Database

Characterization of muscarinic receptors in human submandibular salivary glands. 1985

F Martos, and R Bermudez, and A Gomez, and A Garcia, and F Sanchez de la Cuesta

We studied the binding of the muscarinic antagonist [3H]N-methyl-scopolamine [( 3H]NMS) in order to characterize muscarinic receptors located in human submandibular salivary glands obtained from intrasurgical biopsy. [3H]NMS bound with a Kd value of 1.56 nM to a single class of muscarinic receptors (Bmax 37.3 fmol/mg protein) since pirenzepine exhibited a homogeneous binding profile.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008566	Membranes	Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.	Membrane Tissue,Membrane,Membrane Tissues,Tissue, Membrane,Tissues, Membrane
D011976	Receptors, Muscarinic	One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.	Muscarinic Acetylcholine Receptors,Muscarinic Receptors,Muscarinic Acetylcholine Receptor,Muscarinic Receptor,Acetylcholine Receptor, Muscarinic,Acetylcholine Receptors, Muscarinic,Receptor, Muscarinic,Receptor, Muscarinic Acetylcholine,Receptors, Muscarinic Acetylcholine
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012602	Scopolamine Derivatives	Analogs or derivatives of scopolamine.	Scopolamines,Derivatives, Scopolamine
D013363	Submandibular Gland	One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)	Submaxillary Gland,Gland, Submandibular,Gland, Submaxillary,Glands, Submandibular,Glands, Submaxillary,Submandibular Glands,Submaxillary Glands
D019832	N-Methylscopolamine	A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.	DD-234,Hyoscine Methiodide,Hyoscine Methobromide,Methscopolamine,Methylscopolamine Nitrate,Methylscopolammonium Methylsulfate,N-Methylscine Methylsulfate,N-Methylscopolamine Bromide,N-Methylscopolamine Iodide,N-Methylscopolamine Methylchloride,N-Methylscopolamine Methylsulfate,N-Methylscopolamine Nitrate,Scopolamine Methylbromide,Skopyl,Ulix,Bromide, N-Methylscopolamine,DD 234,DD234,Iodide, N-Methylscopolamine,Methiodide, Hyoscine,Methobromide, Hyoscine,Methylbromide, Scopolamine,Methylchloride, N-Methylscopolamine,Methylsulfate, Methylscopolammonium,Methylsulfate, N-Methylscine,Methylsulfate, N-Methylscopolamine,N Methylscine Methylsulfate,N Methylscopolamine,N Methylscopolamine Bromide,N Methylscopolamine Iodide,N Methylscopolamine Methylchloride,N Methylscopolamine Methylsulfate,N Methylscopolamine Nitrate,Nitrate, Methylscopolamine,Nitrate, N-Methylscopolamine
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In