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Estradiol-17 beta treatment of adult male Xenopus laevis induces liver parenchymal cells to synthesize DNA and proliferate. DNA synthesis begins 3 to 4 days after estrogen treatment and continues for approximately 10 days. Over this 2-week period, the total number of liver parenchymal cells increases fourfold, the wet weight of the liver remains constant, and there is a 50% reduction in cell volume. The elevated number of cells persists for several months and then returns to the control value. The extent of proliferation is hormone dose dependent. Pulse-chase experiments demonstrate that as a result of hormone treatment a minority of the parenchymal cells in the initial population enter the cell cycle, and via repeated divisions become the majority (79%) of the population by Day 14. The implications of this phenomenon for estrogen-induced liver cell differentiation and vitellogenin gene function are discussed.
R J Spolski, and
W Schneider, and
L J Wangh
August 1986,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
R J Spolski, and
W Schneider, and
L J Wangh
January 1981,
Development, growth & differentiation,
R J Spolski, and
W Schneider, and
L J Wangh
June 1987,
Developmental biology,
R J Spolski, and
W Schneider, and
L J Wangh
September 1961,
Nature,
R J Spolski, and
W Schneider, and
L J Wangh
January 2000,
Nutrition and cancer,
R J Spolski, and
W Schneider, and
L J Wangh
January 1979,
Ontogenez,
R J Spolski, and
W Schneider, and
L J Wangh
November 2010,
Behavioral ecology and sociobiology,
R J Spolski, and
W Schneider, and
L J Wangh
November 1978,
Endocrinology,
R J Spolski, and
W Schneider, and
L J Wangh
January 1964,
Laboratory investigation; a journal of technical methods and pathology,
R J Spolski, and
W Schneider, and
L J Wangh
June 1976,
Hormones and behavior,
