-transparent.png){kind=logo}
The effects of ethyl alcohol (EtOH) on the contractile activities of canine gastric corpus and fundus circular muscles were studied. EtOH, 0.1 to 1%, inhibited phasic contractions of corpus muscles but enhanced tonic contractions. These effects were both concentration dependent. The same range of EtOH concentrations caused a transient rise followed by a fall in the level of tone of fundic muscles. The effects of EtOH on ACh-stimulated contractions were also studied. Phasic contractions were stimulated by ACh and inhibited by EtOH. EtOH augmented the tone responses of both corpus and fundus muscles to ACh. Experiments were also performed to test whether EtOH had specific and direct effects on these muscles. The effects of EtOH were apparently not mediated by prostaglandins or Ach and were not, at least in corpus muscles, a nonspecific result of the hyperosmolarity of EtOH solutions. The data supplement previous studies on muscles of the distal stomach where the effects of EtOH were inhibitory to phasic contractions. The finding that the proximal stomach responds to EtOH with tonic contraction may help explain some of the controversy in the literature about the effects of EtOH on gastric emptying.
K M Sanders, and
R G Berry
January 1978,
Acta physiologica et pharmacologica Bulgarica,
K M Sanders, and
R G Berry
January 1979,
The Japanese journal of physiology,
K M Sanders, and
R G Berry
May 2006,
Experimental and clinical psychopharmacology,
K M Sanders, and
R G Berry
February 1999,
European journal of pharmacology,
K M Sanders, and
R G Berry
January 1983,
Acta physiologica et pharmacologica Bulgarica,
K M Sanders, and
R G Berry
May 2004,
Digestive diseases and sciences,
K M Sanders, and
R G Berry
August 1951,
The Japanese journal of physiology,
K M Sanders, and
R G Berry
June 2018,
Addictive behaviors reports,
K M Sanders, and
R G Berry
May 1979,
Archives internationales de pharmacodynamie et de therapie,
K M Sanders, and
R G Berry
March 2022,
Cellular and molecular neurobiology,
