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The effect of infusing isotonic saline, isotonic and hypertonic glucose, fat emulsion, amino acids. ethanol, and hydrochloric acid into the duodenum on the plasma concentration of immunoreactive secretin was studied in seven normal subjects. Only hydrochloric acid showed any effect. After acidification of the duodenum with hydrochloric acid a significant rise in plasma secretin concentration was observed from 1.3 +/- 0.4 pmol X 1(-1) (mean +/- SEM) to a peak value of 13.0 +/- 1.2 pmol X 1(-1) after 5 min. The concentration returned to the basal level within 15 min. In eight other normal subjects the plasma secretin concentration was measured after the ingestion of a protein-rich meal. No significant changes were observed during the 2 h postprandial period.
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
November 1983,
The American journal of gastroenterology,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
November 1979,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
January 1980,
Scandinavian journal of gastroenterology,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
January 1992,
Beitrage zur gerichtlichen Medizin,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
November 1979,
Acta physiologica Scandinavica,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
November 1980,
The American journal of physiology,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
April 1975,
Gastroenterology,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
October 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
October 1978,
Nihon Naibunpi Gakkai zasshi,
J Fahrenkrug, and
O B Schaffalitzky de Muckadell
August 1955,
The Biochemical journal,
