OBJECTIVE Despite being an integral part of the pediatric workforce, little is known about the current trends and challenges facing pediatric nursing in the United States. The aim of this survey-based analysis was to identify 1) characteristics of the pediatric nursing workforce post-pandemic, 2) data on perceived challenges, 3) examine intent to leave, and 4) quantify compassion fatigue and burnout among pediatric nurses. METHODS A survey-based descriptive design was used for data collection and analysis. Electronic recruitment was used to reach participants from June-August 2023. Descriptive statistics were calculated for all categorical variables to identify trends; subgroup analyses were conducted for main outcome variables including 1) perceived challenges, 2) intent to leave, 3) burnout, and 4) compassion fatigue. RESULTS 6590 United States based pediatric nurses participated, with 93 % identifying as female and over half (60.9 %) indicating employment in direct care roles. The top three concerns post-pandemic included staffing ratios, lower pay than other specialties, and student preparedness to practice. Close to a third of participants indicated that they either intended to leave the profession in the next 5 years (13.1 %), or were unsure if they would stay (17.8 %). Close to a third of respondents reported experiencing compassion fatigue and burnout either often or daily. Years of experience were associated with both burnout (p < .001) and compassion fatigue (p < .001), with both dropping after 16 years of experience. CONCLUSIONS Significant challenges face the pediatric nursing workforce, including high levels of burnout, compassion fatigue, intent to leave the profession, and concerns regarding adequate staffing.