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Effects of administration of tri-iodothyronine (T3) on activities of cardiac and renal pyruvate dehydrogenase complex (active form, PDHa) were investigated. In fed rats, T3 treatment did not affect cardiac or renal PDHa activity, although blood non-esterified fatty acid and ketone-body concentrations were increased. Starvation (48 h) of both control and T3-treated rats resulted in similar increases in the steady-state concentrations of fatty acids and ketone bodies, but inactivation of cardiac and renal pyruvate dehydrogenase complex activities was diminished by T3 treatment. Inhibition of lipolysis increased renal and cardiac PDHa in control but not in T3-treated 48 h-starved rats, despite decreased fatty acid and ketone-body concentrations in both groups. The results suggest that hyperthyroidism influences the response of cardiac and renal PDHa activities to starvation through changes in the metabolism of lipid fuels in these tissues.
M J Holness, and
T N Palmer, and
M C Sugden
March 1979,
The New England journal of medicine,
M J Holness, and
T N Palmer, and
M C Sugden
August 1963,
British journal of pharmacology and chemotherapy,
M J Holness, and
T N Palmer, and
M C Sugden
August 1979,
The Biochemical journal,
M J Holness, and
T N Palmer, and
M C Sugden
October 1986,
Biochimica et biophysica acta,
M J Holness, and
T N Palmer, and
M C Sugden
March 1979,
The Journal of pediatrics,
M J Holness, and
T N Palmer, and
M C Sugden
January 1990,
The American journal of physiology,
M J Holness, and
T N Palmer, and
M C Sugden
January 1986,
The Journal of biological chemistry,
M J Holness, and
T N Palmer, and
M C Sugden
December 1978,
Clinical science and molecular medicine. Supplement,
M J Holness, and
T N Palmer, and
M C Sugden
August 1999,
Diabetes,
M J Holness, and
T N Palmer, and
M C Sugden
December 1997,
FEBS letters,
