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Female mouse fetuses that develop in utero implanted between two male fetuses (2M females) are shown as adults to have significantly elevated (P less than 0.01) levels of beta-glucuronidase activity in their preputial glands compared to that of OM females, females that had not been contiguous to males in utero, and 1M females, females contiguous in utero to only one male (mean +/- SEM, 2M females = 23,9 +/- 2.1, 1M females = 13.3 +/- 5.2, and OM females = 7.8 +/- 2.5 Modified Sigma Units/mg frozen weight). It is hypothesized that the increased enzymatic activity in the preputial glands of 2M females could be important in releasing steroid metabolites from voided urine. These metabolites could then act as pheromones and thus explain some of the described differences in sexual behavior correlated with intrauterine position.
R Wechman, and
M Brown, and
F Hilton
January 2020,
Pediatric pulmonology,
R Wechman, and
M Brown, and
F Hilton
November 1994,
Proceedings of the National Academy of Sciences of the United States of America,
R Wechman, and
M Brown, and
F Hilton
January 1986,
Physiology & behavior,
R Wechman, and
M Brown, and
F Hilton
June 1994,
Physiology & behavior,
R Wechman, and
M Brown, and
F Hilton
June 1986,
Hormones and behavior,
R Wechman, and
M Brown, and
F Hilton
January 2001,
Physiology & behavior,
R Wechman, and
M Brown, and
F Hilton
February 1995,
Physiology & behavior,
R Wechman, and
M Brown, and
F Hilton
March 1986,
Hormones and behavior,
R Wechman, and
M Brown, and
F Hilton
September 1990,
Urology,
R Wechman, and
M Brown, and
F Hilton
February 2008,
Archives of sexual behavior,
