Biomaterial Database

Confidence intervals for multiple-dose concentrations in the one-compartment open model with rapid intravenous injection. 1985

K F Karpinski

The parameters in a multiple-dose compartmental model can be estimated from plasma concentration observations after a single dose of drug. These estimates can be used to obtain confidence intervals for the multiple-dose concentrations. However, since the models are non-linear functions of the parameters, no exact confidence interval procedures are available. In this paper a conservative interval estimation procedure is applied to the one-compartment open model with rapid intravenous injection. Also, extended tables required in the estimation procedure are provided.

UI	MeSH Term	Description	Entries
D007275	Injections, Intravenous	Injections made into a vein for therapeutic or experimental purposes.	Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration