-transparent.png){kind=logo}
The concept that creatine phosphokinase is bound to the outer surface of the heart mitochondrial inner membrane originated from observations that the enzyme is retained by water-swollen heart mitochondria and by digitonin-treated heart mitochondria suspended in isotonic sucrose. The present study establishes that digitonin-treated mitochondria release creatine phosphokinase in isotonic KCl, and other investigators have reported an identical response for the water-swollen organelles. These observations suggest that mitochondrial creatine phosphokinase is not bound to the outer surface of the inner membrane at a site adjacent to the adenine nucleotide translocase under physiologic conditions.
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
January 1982,
Biochemical pharmacology,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
January 1989,
Journal of receptor research,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
May 1973,
Chemistry and physics of lipids,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
January 1986,
Advances in experimental medicine and biology,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
December 1993,
Biochimica et biophysica acta,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
January 1988,
Comparative biochemistry and physiology. B, Comparative biochemistry,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
July 1988,
Biochemical and biophysical research communications,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
March 1980,
Revista espanola de fisiologia,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
April 1983,
The Journal of biological chemistry,
W C Wenger, and
M P Murphy, and
G P Brierley, and
R A Altschuld
March 1995,
Biochimica et biophysica acta,
