Case is described with acute renal failure in Henoch's nephritis with intra- and extracapillary cellular proliferation. The disease was manifested with its classical picture: characteristic purpura, articular pains in the wrist and ankle joints, mucous-bloody diarrhea. The renal changes originated at the very beginning of the hemorrhagic vasculitis and clinically was manifested with acute renal failure and severe nephrotic syndrome. Under the effect of hemodialysis and complex drug treatment with cytostatics, glucocorticoids, anticoagulants, plasma- and bloodtransfusions, a very good clinical and paraclinical effect was attained. No recurrences of the main disease were recorded during the six-year clinical observation. A stability of the renal function was observed in the patient, with the exception of the persiting proteinuria with values under 10 g/l.