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M. arthritidis PG6 in a dose of 10(7) colony-forming units per ml was shown to produce a highly pronounced mitogenic effect, linked with a thermolabile factor, on the splenocytes of mice and rats. The mitogenic factor was absent in the lipid fraction and in the fraction formed by easily extractable mycoplasmal proteins. The supernatant fluid obtained after the sedimentation of M. arthritidis globular proteins with ammonium sulfate stimulated lymphocytes as actively as the intact culture of M. arthritidis. The fractionation of the supernatant fluid in columns packed with Sephadex G-200 revealed that the greatest mitogenic effect was produced by the fraction with a molecular weight of 240,000 daltons. It seems that the arthritogenic properties of M. arthritidis are linked precisely with this subcomponent.
L G Gorina, and
A V Pronin
January 1986,
Medical laboratory sciences,
L G Gorina, and
A V Pronin
April 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
L G Gorina, and
A V Pronin
December 2005,
American journal of reproductive immunology (New York, N.Y. : 1989),
L G Gorina, and
A V Pronin
March 1986,
Immunobiology,
L G Gorina, and
A V Pronin
March 1979,
Biochimica et biophysica acta,
L G Gorina, and
A V Pronin
December 1986,
Regulatory peptides,
L G Gorina, and
A V Pronin
September 1978,
The Journal of biological chemistry,
L G Gorina, and
A V Pronin
January 1984,
Annales de microbiologie,
L G Gorina, and
A V Pronin
May 1990,
Experimental cell research,
L G Gorina, and
A V Pronin
February 1988,
Journal of neurosurgery,
