Cerebellar foliation in rats. 2. Effects of maternal malnutrition on the formation of fissures in foetal rats. 1985

N G Conradi, and K Müntzing

The effects of maternal malnutrition on the formation of cerebellar fissures was studied in foetal rats. The rats were given a diet containing either 14 (normal) or 7 (protein-deprived) per cent protein by weight from two weeks before conception and throughout gestation. The first day with a sperm-positive vaginal smear was designated as Embryonic day 1 (E 1). Foetuses were examined on days E 19 to 22. In seventy-five foetuses, a sagittal slice of the cerebellum, 3-4 mm thick was embedded in Sorvall embedding medium. Sagittal sections, 2 micron thick were cut at levels 100 micron apart through the specimen. Sixty-three foetuses were examined for presence of cerebellar fissures only after filling their vascular system with ink-gelatin and cutting serial sagittal frozen sections, 100 micron thick. A morphological comparison of the foliation in normal and malnourished foetuses suggested a slight delay in the malnourished ones, albeit the earliest fissures were visible on the same day as in normal foetuses. The existence of a developmental alteration due to malnutrition was demonstrated by a decrease in the length of the pial surface and a surface folding index day on E 22. The alteration is discussed in relation to previously reported changes in cerebellar development during malnutrition, such as delayed Purkinje cell formation and alterations in proliferation/differentiation in the EGL.

UI MeSH Term Description Entries
D009748 Nutrition Disorders Disorders caused by nutritional imbalance, either overnutrition or undernutrition. Nutritional Disorders,Nutrition Disorder,Nutritional Disorder
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011248 Pregnancy Complications Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases. Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

N G Conradi, and K Müntzing
July 1987, Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
N G Conradi, and K Müntzing
November 1985, Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
N G Conradi, and K Müntzing
July 2001, Acta neuropathologica,
N G Conradi, and K Müntzing
September 1987, Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
N G Conradi, and K Müntzing
November 1980, Developmental psychobiology,
N G Conradi, and K Müntzing
December 1977, Revue francaise de gynecologie et d'obstetrique,
N G Conradi, and K Müntzing
May 2020, Neurology,
N G Conradi, and K Müntzing
July 1987, Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
N G Conradi, and K Müntzing
September 1984, Journal of the Indian Medical Association,
N G Conradi, and K Müntzing
January 1976, Indian journal of physiology and pharmacology,
Copied contents to your clipboard!