Effects of protein depletion and repletion on experimental open wound contraction. 1985

M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves

A controlled comparative study was conducted on the contraction of open wounds in protein-depleted and depleted-repleted Wistar rats. The wounds were photographed on days 1, 4, 8, 11, 15, 18, and 22 after infliction. The slides were projected and the areas corresponding to the wound were measured by planimetry. The results were analyzed using exponential regressions. Wound contraction was slowed in the protein-depleted animals but was normalized in the animals repleted immediately after the wound was produced. Comparing these results with observations from previous studies, the authors inferred that deficiencies in wound contraction in depleted animals are caused by morphological and functional changes in the granulation tissue. These deficiencies are promptly corrected by protein repletion.

UI MeSH Term Description Entries
D008297 Male Males
D011488 Protein Deficiency A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406) Deficiency, Protein,Deficiencies, Protein,Protein Deficiencies
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
December 1978, Annals of surgery,
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
January 1959, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
March 1959, The American journal of physiology,
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
November 1984, Cancer,
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
June 1959, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
January 1977, Physiologia Bohemoslovaca,
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
August 1973, Journal of nutritional science and vitaminology,
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
April 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
March 1981, The Biochemical journal,
M Modolin, and R G Bevilacqua, and N F Margarido, and E Lima-Gonçalves
November 1976, Zentralblatt fur Veterinarmedizin. Reihe A,
Copied contents to your clipboard!