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Immunoglobulin (Gm and Km) allotypes in the Aymara of Chile and Bolivia. 1985

R Chakraborty, and H Gershowitz, and R E Ferrell, and S A Barton, and W J Schull

Immunoglobulin (Gm and Km) allotype and haplotype frequencies are presented for 1707 individuals from Northern Chile and Western Bolivia, subdividing them by ethnicity and altitude of residence. The haplotype distribution of Gm as well as Km loci in these populations suggest that in almost all of the ethnicity x altitude subdivisions of this population considerable admixture of Amerindian and Caucasian genes have occurred. The haplotype frequency heterogeneity and the analysis of departure from Hardy-Weinberg expectations demonstrate that while some local variation in haplotype frequencies at the Gm and Km loci exists in this region, there is no clear evidence suggesting that the pattern of variation is due to an adaptation to the hypoxia of altitude. We conclude that such differences in haplotype frequencies are probably due to random genetic drift and differential admixture of Amerindian and Caucasian genes that have occurred in the past.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007126 Immunoglobulin Allotypes Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES. Allotypes, Immunoglobulin,Allotypic Antibodies,Antibodies, Allotypic,Ig Allotypes,Allotype, Ig,Allotype, Immunoglobulin,Allotypes, Ig,Allotypic Antibody,Antibody, Allotypic,Ig Allotype,Immunoglobulin Allotype
D007199 Indians, South American Members of indigenous South American populations with pre-colonial contact origins. Amerinds, South American,Indigenous South Americans,American Amerind, South,American Indian, South,American, Indigenous South,Americans, Indigenous South,Amerind, South American,Indian, South American,Indigenous South American,South American Amerind,South American Amerinds,South American Indian,South American Indians,South American, Indigenous,South Americans, Indigenous
D001838 Bolivia A country in central South America, located southwest of Brazil.
D002677 Chile A country in southern South America, bordering the South Pacific Ocean, between Argentina and Peru.
D005006 Ethnicity A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships. Ethnic Groups,Nationality,Ethnic Group,Nationalities
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D044465 White People Persons having origins in any of the white racial groups of Europe, the Middle East, or North Africa. Note that OMB category WHITE is available for the United States population groups. Race and ethnicity terms, as used in the federal government, are self-identified social construct and may include terms outdated and offensive in MeSH to assist users who are interested in retrieving comprehensive search results for studies such as in longitudinal studies. European Continental Ancestry Group,White Person,Caucasian Race,Caucasoid Race,Caucasian Races,Caucasoid Races,People, White,Person, White,Race, Caucasian,Race, Caucasoid,White Peoples,White Persons

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