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The extent to which conclusions about myocardial performance may be drawn from end-systolic pressure-volume relations was investigated. Left ventricular isovolumetric and end-systolic pressure-volume relationships were measured in the rat, under acute impairment of contractility (hexobarbital), at chronic pressure overload (spontaneously hypertensive rats), and at chronic volume overload (aorto-caval shunt). Our results confirm the classic conception of Otto Frank where the curves of the isovolumetric maxima and the curves of the end-systolic pressure-volume relations follow separate courses. Acute alterations in contractility can be detected from shifts in the end-systolic pressure-volume relations. In chronic pressure or volume overloaded hearts the end-systolic pressure-volume relations do not render conclusions about ventricular or myocardial performance since in chronically altered hearts, the course of the end-systolic pressure-volume relations is primarily influenced by geometric factors.
G Kissling, and
N Takeda, and
M Vogt
June 1988,
The American journal of physiology,
G Kissling, and
N Takeda, and
M Vogt
June 1984,
Circulation research,
G Kissling, and
N Takeda, and
M Vogt
January 1981,
The Kurume medical journal,
G Kissling, and
N Takeda, and
M Vogt
September 1980,
The American journal of cardiology,
G Kissling, and
N Takeda, and
M Vogt
October 1995,
Critical care medicine,
G Kissling, and
N Takeda, and
M Vogt
March 1986,
Circulation,
G Kissling, and
N Takeda, and
M Vogt
May 1979,
The American journal of cardiology,
G Kissling, and
N Takeda, and
M Vogt
June 1985,
Circulation,
G Kissling, and
N Takeda, and
M Vogt
March 2002,
Heart and vessels,
G Kissling, and
N Takeda, and
M Vogt
October 2002,
Journal of the American College of Cardiology,
