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The authors studied pituitary thyrotropin, i.e., thyroid-stimulating hormone (TSH), response to thyrotropin-releasing hormone (TRH) in patients with primary affective disorder. There were no overall differences between either depressed or manic patients and normal controls; however, the TSH response was significantly lower in the unipolar depressed patients than in either bipolar depressed patients or normal subjects. Bipolar patients in the manic phase tended to have a lower response than bipolar depressed patients. In the unipolar group, the TSH response showed a significant negative correlation with the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the CSF. These neuroendocrine responses may constitute markers of specific monoamine dysfunction in subgroups of patients with affective illness.
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
November 1976,
Archives of general psychiatry,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
November 1989,
Nihon Seikeigeka Gakkai zasshi,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
January 1973,
The American journal of psychiatry,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
January 1973,
The American journal of psychiatry,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
January 1976,
Annales d'endocrinologie,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
June 1988,
Rinsho shinkeigaku = Clinical neurology,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
July 1975,
The Journal of clinical endocrinology and metabolism,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
April 1973,
Lancet (London, England),
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
March 1991,
Age and ageing,
P W Gold, and
F K Goodwin, and
T Wehr, and
R Rebar
October 1973,
The Journal of clinical endocrinology and metabolism,
