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Previous studies have demonstrated that certain high fat diets can induce peroxisomal fatty acid beta-oxidation in rodent liver and that this may be due to their content of trans 22:1 fatty acids. In this study we have examined the effects of cis and trans 22:1 fatty acids (erucic and brassidic) and oleic acid (18:1) on palmitoyl-CoA oxidation, carnitine acetyltransferase and carnitine palmitoyltransferase activities in primary rat hepatocyte cultures. Brassidic and erucic acid and, to a lesser extent, oleic acid were cytotoxic to rat hepatocytes. However, at a concentration of 0.1 mM, brassidic acid produced small increases in palmitoyl-CoA oxidation and carnitine acetyltransferase activities in hepatocytes cultured 70 hr. Treatment of cells with 0.1 and 0.3 mM of either erucic or oleic acid had no effect on any of the enzymes measured.
E N Christiansen, and
T J Gray, and
B G Lake
October 1990,
Biochemical and biophysical research communications,
E N Christiansen, and
T J Gray, and
B G Lake
March 1979,
FEBS letters,
E N Christiansen, and
T J Gray, and
B G Lake
January 1992,
Advances in experimental medicine and biology,
E N Christiansen, and
T J Gray, and
B G Lake
February 1987,
The Biochemical journal,
E N Christiansen, and
T J Gray, and
B G Lake
June 1987,
Clinica chimica acta; international journal of clinical chemistry,
E N Christiansen, and
T J Gray, and
B G Lake
November 1987,
The Biochemical journal,
E N Christiansen, and
T J Gray, and
B G Lake
August 1990,
The Biochemical journal,
E N Christiansen, and
T J Gray, and
B G Lake
November 1992,
Journal of lipid research,
E N Christiansen, and
T J Gray, and
B G Lake
January 1992,
Journal of inherited metabolic disease,
E N Christiansen, and
T J Gray, and
B G Lake
January 1993,
Biochimie,
