Biomaterial Database

Effects of the water-soluble carcinogen 4-nitroquinoline N-oxide on hamster lingual mucosa. 1977

J W Eveson, and D G MacDonald

The water-soluble carcinogen 4-nitroquinoline N-oxide (4NQO) was painted onto hamster ventral lingual mucosa twice weekly for up to 20 weeks. No neoplasms developed during this period. The promoting agent croton oil was applied to the treated areas in an attempt to determine whether initiation had occurred. During the following 6 months, one animal developed a papilloma and three animals showed areas of epithelial atypia in the treated mucosa. No malignant neoplasms were seen. Despite its efficiency in producing intraoral neoplasms in the rat, 4NQO would appear to be a poor choice in the hamster.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008647	Mesocricetus	A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research.	Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D009600	Nitroquinolines	Quinolines substituted in any position by one or more nitro groups.
D003436	Croton Oil	Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.	Oil, Croton
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D014059	Tongue	A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.	Tongues
D014060	Tongue Diseases	Diseases involving the TONGUE.	Microglossia,Disease, Tongue,Diseases, Tongue,Microglossias,Tongue Disease
D014867	Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Hydrogen Oxide