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The technique of labelled mitoses was used to investigate the cell proliferation kinetics in two human neoplasms, one a malignant melanoma and one a fibrosarcoma, transplanted to and grown serially in the athymic nude mutant (ANM) mouse. The experimental data obtained codrealted well with a theoretical percentage labelled mitoses curve based on the assumption that the time spent by a cell in each of the phases M, G1, S and G2 is described by four independent log-normal distributions. However, no unique second wave was defined by the experimental results. This means that only the deductions made about the duration of the G2 and S phases are reliable. The median duration of tma and the fibrosarcoma, respectively. By comparing these results with results published on cell cycle studies of transplantable animal tumors and human tumors in situ, it is concluded that the cell cycle parameters of a human tumor grown in the ANM mouse are close to those of the same tumor in the donor patient.
E K Rofstad, and
T Brustad, and
O Kaalhus
January 1985,
Journal of cancer research and clinical oncology,
E K Rofstad, and
T Brustad, and
O Kaalhus
December 1979,
International journal of cancer,
E K Rofstad, and
T Brustad, and
O Kaalhus
July 1984,
Cell and tissue kinetics,
E K Rofstad, and
T Brustad, and
O Kaalhus
March 1987,
Acta pathologica japonica,
E K Rofstad, and
T Brustad, and
O Kaalhus
March 1982,
Transplantation,
E K Rofstad, and
T Brustad, and
O Kaalhus
October 1974,
International journal of cancer,
E K Rofstad, and
T Brustad, and
O Kaalhus
June 1984,
European journal of cancer & clinical oncology,
E K Rofstad, and
T Brustad, and
O Kaalhus
April 1980,
European journal of cancer,
E K Rofstad, and
T Brustad, and
O Kaalhus
March 1977,
International journal of cancer,
E K Rofstad, and
T Brustad, and
O Kaalhus
January 1989,
Head & neck,
