-transparent.png){kind=logo}
A patient with combined factor VII and factor VIII deficiency is discussed. The propositus is a 21-year-old male who presented a mild bleeding tendency. The patient appears to be a hemophilia and at the same time heterozygote for factor VII deficiency. This conclusion is based on the fact that heterozygosis for factor VII deficiency was present in the father and in other relatives of the paternal side. On the contrary, no factor VII deficiency was present in the maternal side of the family. However, the maternal grandfather was known to have been a bleeder and the propositus' mother, his sister and his aunt had low-normal factor VIII levels and were probably hemophilia A carriers. This type of combined factor VII and factor VIII deficiency appears to be due to the casual association of two independently segregating defects.
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
January 1980,
Acta haematologica,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
December 2021,
Hematology/oncology clinics of North America,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
January 1977,
Folia haematologica (Leipzig, Germany : 1928),
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
January 1976,
Acta haematologica,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
October 1977,
Blood,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
February 1993,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
December 1973,
Minerva pediatrica,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
December 1973,
Blood,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
January 1971,
Bullettino delle scienze mediche,
A Girolami, and
R Dal Bo Zanon, and
F Fabris, and
R Franzoso
January 1995,
Advances in experimental medicine and biology,
