Biomaterial Database

[Study of the interrelationships of amprolium-thiamine, Coccidia and coccidiosis in chicks]. 1977

Sh Sherkov

A total of 180 birds, divided into 9 groups of 20 each, were used in tests to elucidate the prophylactic value of the coccidiostatic drug Amprolium in the suggested dose of 125 g per ton feed, and given at the rate of a four-fold high dose (500 g/ton), with and without additional amounts of thiamine incorporated into the standard mixtures. It was found that Amprolium could hardly suppress to a full extent the excretion of oocysts in doses which were as high as 500 g/ton. When using additional amounts of thiamine such effect could not be produced. It is believed that thiamine contributes to the lowering of the activity of the preparation as well as to be prolongation of the parasite development in the intestine and the increase in the asexual populations and oocyst excretion by 66 per cent. In cases where poultry farms are infected despite the use of Amprolium it is suggested to make it clear with objectivity to what extent coccidiosis is due to the resistance phenomenon or the lowering in the activity of the preparation as a result of the higher concentration of thiamine in the feed mixture, and to effect the respective correction so as to reach an optimal ration of the components.

UI	MeSH Term	Description	Entries
D010847	Picolines	A group of compounds that are monomethyl derivatives of pyridines. (From Dorland, 28th ed)	Picoline
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D003044	Coccidia	A subclass of protozoans commonly parasitic in the epithelial cells of the intestinal tract but also found in the liver and other organs. Its organisms are found in both vertebrates and higher invertebrates and comprise two orders: EIMERIIDA and EUCOCCIDIIDA.	Coccidias
D003048	Coccidiosis	Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA.	Besnoitiasis,Besnoitiosis,Besnoitiases,Besnoitioses,Coccidioses
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D000670	Amprolium	A veterinary coccidiostat that interferes with THIAMINE metabolism.	Amprol,Amprolium Chloride,Amprolium Hydrochloride,Anticoccid,Noé-Socopharm Hydrochloride,Némaprol,Pyridinium, 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, Chloride (1:1),Chloride, Amprolium,Hydrochloride, Amprolium,Hydrochloride, Noé-Socopharm,Noé Socopharm Hydrochloride
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia