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The effects of altered acid-base balance on the production of urea and the metabolism of glutamine were investigated in the isolated perfused liver and hindquarter of the rat. In the isolated perfused rat liver, lowering of perfusate pH without altering bicarbonate concentration significantly reduced urea production and increased net glutamine synthesis, although the converse did not obtain. In the isolated perfused rat hindquarter when perfusate pH and bicarbonate were simultaneously reduced glutamine synthesis was significantly increased. The combined hepatic and muscle increase in glutamine synthesis accounted for 89% of the decrease in hepatic urea synthesis under these experimental conditions. These changes in nitrogen metabolism are interpreted in terms of adaptations which offset the initial alterations in hydrogen ion homeostasis.
J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
June 1983,
European journal of biochemistry,
J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
October 1993,
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J Oliver, and
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E Bourke
June 1985,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
January 1980,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
March 1972,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
January 1969,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
October 1999,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
September 1970,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
November 1964,
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J Oliver, and
A M Koelz, and
J Costello, and
E Bourke
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