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Exocrine insufficiency of the pancreas was identified by decreased splitting of the ester substrate and thus diminished excretion of fluorescein in the urine of persons with normal pancreatic function (test excretion). Unesterified fluorescein served to ascertain the standard excretion of fluorescein (= 100%). The relation of test excretion to standard excretion was expressed in %. Values of less than 20% in collected urine are pathologic. The range of 20-30% is questionable. Normal persons showed 30% or more. The method described is simple and without problems for the patient. The test was accurate in 93% of patients with a false negative in 1%. Practicability and results recommend the test as a screening method.
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
May 1982,
Lancet (London, England),
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
November 1985,
Scandinavian journal of clinical and laboratory investigation,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
January 1987,
Pancreas,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
June 1981,
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
February 1991,
Archives of disease in childhood,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
July 1990,
Archives of disease in childhood,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
January 1978,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
April 1980,
Monatsschrift fur Kinderheilkunde,
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
February 1980,
Deutsche medizinische Wochenschrift (1946),
H Kaffernik, and
P Klimkeit, and
P Zöfel, and
U Otte, and
J G Meyer-Bertenrath
April 1979,
Deutsche medizinische Wochenschrift (1946),
