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Electron microscope microanalysis, atomic absorption analysis and ultrastructural survey were used to investigate the effects of parenteral cadmium administration on the lateral prostate of rats. Early fine structural changes in the epithelial cells of the prostatic tissue were associated with the detection of cadmium in the cellular organelles and alteration of the subcellular distribution of zinc. Involutionary changes appeared at later stages and differed from the usual castration effects. Basal cells did not regress with the altered physiological conditions but appeared to proliferate in the presence of cadmium. The observations are discussed in relation to the normal mechanisms which control the maintenance of the prostate gland.
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
January 1982,
Urological research,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
October 1958,
Endocrinology,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
January 1980,
Acta medica Polona,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
December 1965,
Endocrinology,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
February 1960,
Experimental cell research,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
October 1988,
The Journal of endocrinology,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
January 1976,
Acta anatomica,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
January 1970,
Rassegna trimestrale di odontoiatria,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
August 1979,
Biochemical and biophysical research communications,
B G Timms, and
J A Chandler, and
M S Morton, and
G V Groom
August 1981,
Archives of andrology,
