-transparent.png){kind=logo}
Plasma half-life and metabolic clearance rate of antipyrine administered intravenously in a dose of 16 mg/kg body weight was studied in 10 children suffering from protein calorie malnutrition and five normal children matched in age and sex. Plasma half-life was increased and metabolic clearance rate was decreased in malnourished children (10.4 hr and 47.1 ml/hr per kg, respectively) in comparison to controls (6.3 hr and 70.1 ml/hr per kg, respectively). This observation indirectly reflects the lowered activity of microsomal oxidative enzyme of liver. Five children were restudied after nutritional rehabilitation of 17 to 25 days. Antipyrine plasma half-life decreased to 6.6 hr and metabolic clearance rate increased to 66.5 ml/hr per kg. These values were similar to those in normal children indicating biological recovery. The drug therapy in children with protein calorie malnutrition requires reconsideration in light of these observations.
R K Narang, and
S Mehta, and
V S Mathur
April 1979,
Archives of disease in childhood,
R K Narang, and
S Mehta, and
V S Mathur
May 1988,
Boletin medico del Hospital Infantil de Mexico,
R K Narang, and
S Mehta, and
V S Mathur
November 1995,
Biopharmaceutics & drug disposition,
R K Narang, and
S Mehta, and
V S Mathur
February 2021,
Pharmaceutics,
R K Narang, and
S Mehta, and
V S Mathur
May 1954,
Pediatrics,
R K Narang, and
S Mehta, and
V S Mathur
January 1985,
Paediatrica Indonesiana,
R K Narang, and
S Mehta, and
V S Mathur
August 1981,
British journal of clinical pharmacology,
R K Narang, and
S Mehta, and
V S Mathur
October 1977,
The Journal of tropical pediatrics and environmental child health,
R K Narang, and
S Mehta, and
V S Mathur
July 1969,
Zeitschrift fur Morphologie und Anthropologie,
R K Narang, and
S Mehta, and
V S Mathur
February 1981,
The Indian journal of medical research,
