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Immunological reactivity was studied in 76 breast cancer patients taking into consideration the extent of disease and mode of treatment. The following tests were used: delayed hypersensitivity skin reaction after application of tissue antigens from mammary cancer and embryonal tissues prepared by Westphal's method (Silber's modification), tuberculin and 2,4-dinitrochlorbenzene (DCNB). Humoral immune reactivity was evaluated with a mikroprecipitation test using antigens from fetal, tumorous and spleen cells. Tests were performed before and after treatment. The results confirm that positive skin reactions are found mostly in stage I and II. In advanced stages depression of all immune reactions was seen. Some changes of immune reactivity depend on the mode of treatment. Immune competence was not depressed by surgical treatment and the most distinct immune depression was provoked by cytostatic chemotherapy. Our observations suggest that the cytostatics Thiophosphamid, Cyclophosphamid and Fluorouracil are immundepressants.
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
July 1977,
Rinsho byori. The Japanese journal of clinical pathology,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
January 1980,
Bulletin du cancer,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
July 1976,
Rontgen-Blatter; Zeitschrift fur Rontgen-Technik und medizinisch-wissenschaftliche Photographie,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
January 1977,
Zentralblatt fur Chirurgie,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
March 1981,
La Nouvelle presse medicale,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
August 1980,
Dermatologische Monatschrift,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
October 1978,
Archiv fur Gynakologie,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
March 1978,
Revista medica de Chile,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
April 1979,
Praxis und Klinik der Pneumologie,
S I Sergejew, and
W W Gorodilowa, and
A P Baschenowa, and
E W Mandrik, and
I W Kasjanow
September 1981,
Medicina clinica,
