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Experiments were carried out to test the validity of the hypothesis that postulated differences in the nature of the antigen receptors of primary and secondary B cells should be reflected in a greater specificity in primary B-cell stimulation (2). Enumeration of clonal precursors stimulated by either DNP-Hy, TNP-Hy, or a mixture of both antigens confirmed this hypothesis. Since the sum of primary B cells stimulated by DNP-Hy and TNP-Hy is approximately equal to the number stimulated by a mixture of both, overlap stimulation of primary B cells by these antigens could be considered negligible. In contrast, the stimulation of B cells from mice previously immunized with DNP-Hy showed extensive overlap of stimulation by DNP-Hy and TNP-Hy. Thus secondary B cells appear less fastidious in their affinity requirements for stimulation than primary B cells.
N R Klinman, and
J L Press, and
G P Segal
January 1969,
Israel journal of medical sciences,
N R Klinman, and
J L Press, and
G P Segal
August 2013,
Current opinion in allergy and clinical immunology,
N R Klinman, and
J L Press, and
G P Segal
December 1988,
The American journal of medicine,
N R Klinman, and
J L Press, and
G P Segal
September 1986,
Immunology today,
N R Klinman, and
J L Press, and
G P Segal
May 1966,
Biochimica et biophysica acta,
N R Klinman, and
J L Press, and
G P Segal
May 1977,
Journal of immunology (Baltimore, Md. : 1950),
N R Klinman, and
J L Press, and
G P Segal
March 1981,
Biochemical and biophysical research communications,
N R Klinman, and
J L Press, and
G P Segal
August 1973,
The Journal of experimental medicine,
N R Klinman, and
J L Press, and
G P Segal
May 1972,
Journal of clinical pathology,
N R Klinman, and
J L Press, and
G P Segal
March 2019,
Reproduction, fertility, and development,
