Understanding Glycemia in the Post Discharge Period Through Blinded Continuous Glucose Monitoring. 2025

Rahul Patel, and Mollie Y O'Connor, and Amy Sabean, and Annabelle Ashley, and Hui Zheng, and Joyce Yan, and Barbara A Steiner, and Nillani Anandakugan, and Melissa Calverley, and Rachel Bartholomew, and Evelyn Greaux, and Mary Larkin, and Steven J Russell, and Melissa S Putman, and Kristen L Flint
Diabetes Research Center, Massachusetts General Hospital, Boston, MA.

OBJECTIVE Transitions of care at hospital discharge are critical time periods for people with diabetes, but little is known about glycemia in the immediate post-discharge period. METHODS In this observational study, participants wore blinded Dexcom G6 Pro CGM during hospital admission on non-intensive care floors and then continued wearing blinded CGM for up to 10 days post-hospital discharge. Clinical data were extracted from the electronic medical record. Percent time in range 70-180 mg/dl (TIR), above range (TAR), and below range (TBR) from the inpatient and post-discharge periods were calculated. The percentage of participants achieving TIR >50% and >70%, incidence of hypoglycemia after discharge, change in inpatient and post-discharge CGM metrics, and predictors of post-discharge glycemia were determined. RESULTS A total of 24 adults (mean age 65.7 ± 13.6 years, 37.5% female) wore CGM after discharge with mean TIR 43.9 ± 33.2%, mean TAR 55.9 ± 33.3%, and median TBR 0% (0, 0.04). Of these participants, 41.7% had TIR >50%, and 29.2% had TIR >70%. Glycemia pre- and post-discharge was similar (post-discharge vs inpatient TIR -3.7 ± 22.5%, p=0.4). Of the clinical factors assessed, only inpatient glycemia was associated with achieving post-discharge glycemic targets. CGM detected 13 episodes of hypoglycemia occurring in six participants (25%) post-discharge. CONCLUSIONS Glycemia during the post-discharge period is suboptimal, and glucose levels in the hospital may be an important predictor of glycemia after hospitalization. CGM may be useful in identifying hypoglycemia after discharge. Further studies are needed to understand the utility of CGM after hospital discharge.

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