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In an initial safety study, phosphorus-32 (as diphosphonate) was administered intravenously to five patients with painful bone metastases from prostatic carcinoma; two patients received 9 mCi and three were given 3 mCi. Hematological, biochemical, ECG, x-ray, bone-scan data, and clinical observation, were followed for 2 mo. At both dose levels, bone-marrow depression was noted. One of the patients, who received 9 mCi, had only a slight dip in the levels of circulating white blood cells and platelets. The other 9-mCi patient was the only one with discrete metastases by bone scan; he had bone-marrow depression, from which he recovered, and was the only one of the five who had relief of bone pain.
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
February 1971,
Radiology,
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
June 1966,
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca,
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
October 1994,
Journal of hepatology,
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
January 1988,
Acta oncologica (Stockholm, Sweden),
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
December 1985,
The Journal of urology,
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
January 1983,
Lancet (London, England),
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
January 1971,
Scandinavian journal of urology and nephrology,
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
October 1988,
Hinyokika kiyo. Acta urologica Japonica,
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
June 1975,
Wiener medizinische Wochenschrift (1946),
M S Potsaid, and
R J Irwin, and
F P Castronovo, and
G R Prout, and
W J Harvey, and
M D Francis, and
A J Tofe, and
R G Zamenhof
February 1988,
The Annals of thoracic surgery,
