Biomaterial Database

Infection protective property of the common antigen (OEP) of Pseudomonas aeruginosa and its chemical composition. 1977

C Abe, and K I Tanamoto, and J Y Homma

The protein moiety (OEP) of the endotoxin of Pseudomonas aeruginosa is a proteinaceous compound composed of possessing 77% protein and a small amount of lipid and sugar. The antigen has been proved to possess a common protective property against P. aeruginosa infections regardless of serotype and also to possess an antigen common to all the serotype strains of P. aeruginosa. When OEP was subjected to protease digestion, (protease-treated OEP) the protein content was reduced to 17% without a change in the lipid and sugar composition. The protease-treated OEP was no longer found to possess a serologically common antigen and was also found to have lost the common protective property against infections due to all the serotypes of P. aeruginosa. In conclusion, a serologically common antigen (OEP) as well as a common infection protective property was found to reside in a protein portion of the antigen.

UI	MeSH Term	Description	Entries
D011550	Pseudomonas aeruginosa	A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.	Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D000942	Antigens, Bacterial	Substances elaborated by bacteria that have antigenic activity.	Bacterial Antigen,Bacterial Antigens,Antigen, Bacterial
D001426	Bacterial Proteins	Proteins found in any species of bacterium.	Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial