-transparent.png){kind=logo}
In order to clarify the influences of situational factors on the effects of psychotropic drugs, the sedative effects of tetrabenazine after injection at various times of the day were studied. When 50 mg/kg body weight of tetrabenazine was injected into rats at eight different times of the day (07:30-19:30 dark, 19:30-07:30 light), a circadian rhythm of sedative effect was observed with a peak sedative time of 1490 min at 10:30 and a nadir of 736 min at 07:30. With 10 mg/kg body weight of tetrabenazine a similar circadian rhythm of sedative effect was observed. This rhythm did not appear to be due to differences of metabolism of tetrabenazine in the tissues, but rather to be closely related to daily fluctuation of serotonin synthesis and release in the brain.
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
January 1974,
Chronobiologia,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
April 1989,
Masui. The Japanese journal of anesthesiology,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
January 1978,
Chronobiologia,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
April 1968,
The Anatomical record,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
May 2002,
Photochemistry and photobiology,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
August 2022,
Expert review of anti-infective therapy,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
December 1994,
Zhonghua fu chan ke za zhi,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
February 1970,
Journal of economic entomology,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
January 1983,
The Journal of investigative dermatology,
H Nagayama, and
A Takagi, and
T Tateishi, and
R Takahashi
February 1984,
The Journal of the Arkansas Medical Society,
