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A new water-soluble myelographic contrast agent with more hydrophilic properties than metrizamide was developed and tested in the primate (Macaca mulatta) and the cat. A new animal model that allows study of the convulsive effects of intrathecally administered contrast agents in the awake monkey was designed. With this sensitive model the new contrast agent was shown to have a remarkable reduced convulsive effect when compared with metrizamide and other media. Intrathecal hypertonic solutions in the cat depress the evoked cortico-spinal responses whereas the neurotoxic effects of the iodinated water-soluble contrast media increase them. The net effect is a combination of the two actions.
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
May 1989,
Presse medicale (Paris, France : 1983),
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
May 1981,
The British journal of radiology,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
January 1955,
Fortschritte auf dem Gebiete der Rontgenstrahlen,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
November 1985,
Clinical radiology,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
February 1977,
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
January 1985,
Investigative radiology,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
January 1985,
AJNR. American journal of neuroradiology,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
January 1964,
Vestnik rentgenologii i radiologii,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
December 1976,
Acta ophthalmologica,
S K Hilal, and
G W Dauth, and
K H Hess, and
S Gilman
January 1982,
Journal of neurosurgical sciences,
